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Báo cáo y học: " Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells"

Tham khảo luận văn - đề án 'báo cáo y học: " influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Respiratory Research BioMed Central Open Access Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells Yaqin Xuf1 Christine TertilC2 4 Anja Krause2 Luis EN Quadri3 Ronald G Crystal2 and Stefan Worgall 1 2 Address Department of Pediatrics Weill Cornell Medical College New York USA 2Department of Genetic Medicine Weill Cornell Medical College New York USA 3Department of Microbiology and Immunology Weill Cornell Medical College New York USA and 4Department of Immunology Johannes Gutenberg University Mainz Germany Email Yaqin Xu - yax2002@med.cornell.edu Christine Tertilt - ctertilt@yahoo.de Anja Krause - ank2006@med.cornell.edu Luis EN Quadri - leq2001@med.cornell.edu Ronald G Crystal - rgcryst@med.cornell.edu Stefan Worgall - stw2006@med.cornell.edu Corresponding author fEqual contributors Published 3 April 2009 Received 11 November 2008 Respiratory Research 2009 10 26 doi 10.1186 1465-9921-10-26 Accepted 3 April 2009 This article is available from http respiratory-research.cOm content 10 1 26 2009 Xu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Cystic fibrosis CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator CFTR gene. Infections of the respiratory tract are a hallmark in CF. The host immune responses in CF are not adequate to eradicate pathogens such as P. aeruginosa. Dendritic cells DC are crucial in initiation and regulation of immune responses. Changes in DC function could contribute to abnormal immune responses on multiple levels. The role of DC in CF lung disease remains unknown. Methods This .