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Báo cáo y học: " Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis. | BioMed Central Respiratory Research Research Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis Lynne Bingle1 2 Frances A Barnes2 Simon S Cross3 Doris Rassl4 William A Wallace5 Michael A Campos6 and Colin D Bingle 2 Address Department of Oral Pathology School of Clinical Dentistry University of Sheffield Sheffield UK 2Academic Unit of Respiratory Medicine University of Sheffield Medical School Sheffield UK 3Academic Unit of Pathology University of Sheffield Medical School Sheffield UK 4Department of Pathology Papworth Hospital Cambridge UK 5Department of Pathology University of Edinburgh Edinburgh UK and 6Division of Pulmonary and Critical Care Medicine University of Miami Miami Florida USA Email Lynne Bingle - l.bingle@sheffield.ac.uk Frances A Barnes - f.barnes@sheffield.ac.uk Simon S Cross - s.s.cross@sheffield.ac.uk Doris Rassl - doris.rassl@papworth.nhs.uk William A Wallace - william.wallace@luht.scot.nhs.uk Michael A Campos - mcampos1@med.miami.edu Colin D Bingle - c.d.bingle@sheffield.ac.uk Corresponding author Open Access Published 7 November 2007 Received 9 May 2007 Respiratory Research 2007 8 79 doi 10.1186 1465-9921 -8-79 Accepted 7 November 2007 This article is available from http respiratory-research.cOm content 8 1 79 2007 Bingle et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Short PLUNC1 SPLUNC1 is the founding member of a family of proteins PLUNCS expressed in the upper respiratory tract and oral cavity which may function in host defence. It is one of the most highly expressed genes in the upper airways and the protein has been detected in sputum and nasal secretions. The biology of the PLUNC family is poorly understood but in .