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Báo cáo y học: Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. | Respiratory Research BioMed Central Research Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells Aruna Kode Se-Ran Yang and Irfan Rahman Open Access Address Department of Environmental Medicine Lung Biology and Disease Program University of Rochester Medical Center Rochester NY USA Email Aruna Kode - Aruna_Kode@urmc.rochester.edu Se-Ran Yang - Seran_Yang@urmc.rochester.edu Irfan Rahman - Irfan_Rahman@urmc.rochester.edu Corresponding author Published 24 October 2006 Received 19 July 2006 Respiratory Research 2006 7 132 doi 10.1186 1465-9921-7-132 Accepted 24 October 2006 This article is available from http respiratory-research.com content 7 1 132 2006 Kode et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Cigarette smoke mediated oxidative stress and inflammatory events in the airway and alveolar epithelium are important processes in the pathogenesis of smoking related pulmonary diseases. Previously individual cell lines were used to assess the oxidative and proinflammatory effects of cigarette smoke with confounding results. In this study a panel of human and rodent transformed epithelial cell lines were used to determine the effects of cigarette smoke extract CSE on oxidative stress markers cell toxicity and proinflammatory cytokine release and compared the effects with that of primary human small airway epithelial cells SAEC . Methods Primary human SAEC transformed human A549 H1299 H441 and rodent murine MLE-15 rat L2 alveolar epithelial cells were treated with different .