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Báo cáo y học: " Open Access MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Open Access MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation. | Respiratory Research BioMed Central Research Open Access MMP-9 TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation PF Mercer 1 JK Shute2 A Bhowmik3 GC Donaldson3 JA Wedzicha3 and JA Warner1 Address 1School of Biological Sciences University of Southampton Southampton UK 2Department of Medical Specialties University of Southampton Southampton UK and 3Academic Unit of Respiratory Medicine Royal Free and University College Medical School London UK Email PF Mercer - paul.mercer@ucl.ac.uk JK Shute - jan.shute@port.ac.uk A Bhowmik - angshub@hotpop.com GC Donaldson - g.donaldson@medsch.ucl.ac.uk JA Wedzicha - j.a.wedzicha@medsch.ucl.ac.uk JA Warner - jawarner@soton.ac.uk Corresponding author Published 22 December 2005 Received 27 July 2005 Accepted 22 December 2005 Respiratory Research 2005 6 151 doi 10.1186 1465-9921-6-151 This article is available from http respiratory-research.com content 6 1 151 2005 Mercer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Irreversible airflow obstruction in Chronic Obstructive Pulmonary Disease COPD is thought to result from airway remodelling associated with aberrant inflammation. Patients who experience frequent episodes of acute deterioration in symptoms and lung function termed exacerbations experience a faster decline in their lung function and thus over time greater disease severity However the mechanisms by which these episodes may contribute to decreased lung function are poorly understood. This study has prospectively examined changes in sputum levels of inflammatory cells MMP-9 and TIMP-1 during exacerbations comparing with paired samples taken prior to exacerbation. Methods Nineteen COPD patients median IQR age 69 63 to 74 forced .