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Báo cáo y học: " Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients. | Retrovirology BioMed Central Research Lack of evidence for xenotropic murine leukemia virus-related virus XMRV in German prostate cancer patients Oliver Hohn11 Hans Krause12 Pia Barbarotto1 Lars Niederstadt1 Nadine Beimforde1 3 Joachim Denner4 Kurt Miller2 Reinhard Kurth1 and Norbert Bannert 1 Address 1Robert Koch-Institute Centre for Biological Safety 4 Nordufer 20 13353 Berlin Germany 2Charité - Universitatsmedizin Berlin Urologische Klinik Schumannstrafie 20 21 10117 Berlin Germany 3Charité - Universitatsmedizin Berlin Hindenburgdamm 30 12203 Berlin and 4Robert Koch-Institute Retrovirus induced immunosuppression P13 Nordufer 20 13353 Berlin Germany Email Oliver Hohn - HohnO@rki.de Hans Krause - Hans.Krause@charite.de Pia Barbarotto - pia1412@gmx.de Lars Niederstadt - NiederstadtL@rki.de Nadine Beimforde - BeimfordeN@rki.de Joachim Denner - DennerJ@rki.de Kurt Miller - Kurt.Miller@charite.de Reinhard Kurth - KurthR@rki.de Norbert Bannert - bannertn@rki.de Corresponding author fEqual contributors Open Access Published 16 October 2009 Received 3 July 2009 Retrovirology 2009 6 92 doi 10.1186 1742-4690-6-92 Accepted 16 October 2009 This article is available from http www.retrovirology.com content 6 1 92 2009 Hohn et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A novel gammaretrovirus named xenotropic murine leukemia virus-related virus XMRV has been recently identified and found to have a prevalence of 40 in prostate tumor samples from American patients carrying a homozygous R462Q mutation in the RNaseL gene. This mutation impairs the function of the innate antiviral type I interferon pathway and is a known susceptibility .

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