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Báo cáo y học: " Identification of two distinct structural regions in a human porcine endogenous retrovirus receptor, HuPAR2, contributing to function for viral entry"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of two distinct structural regions in a human porcine endogenous retrovirus receptor, HuPAR2, contributing to function for viral entry. | Retrovirology BioMed Central Open Access Identification of two distinct structural regions in a human porcine endogenous retrovirus receptor HuPAR2 contributing to function for viral entry Katherine T Marcucci1 3 Takele Argaw2 Carolyn A Wilson2 and Daniel R Salomon 1 Address Department of Molecular and Experimental Medicine The Scripps Research Institute La Jolla CA 92037 USA 2Division of Cellular and Gene Therapies Center for Biologics Evaluation and Research U.S. Food and Drug Administration Bethesda MD 20892 USA and 3Department of Pediatrics Children s Hospital of Philadelphia Philadelphia Pennsylvania 19104 USA Email Katherine T Marcucci - marcuccik@email.chop.edu Takele Argaw - takele.argaw@fda.hhs.gov Carolyn A Wilson - carolyn.wilson@fda.hhs.gov Daniel R Salomon - dsalomon@scripps.edu Corresponding author Published 14 January 2009 Received 16 October 2008 Accepted 14 January 2009 Retrovirology 2009 6 3 doi l0.ll86 l742-4690-6-3 This article is available from http www.retrovirology.cOm content 6 1 3 2009 Marcucci et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Of the three subclasses of Porcine Endogenous Retrovirus PERV PERV-A is able to infect human cells via one of two receptors HuPAR1 or HuPAR2. Characterizing the structurefunction relationships of the two HuPAR receptors in PERV-A binding and entry is important in understanding receptor-mediated gammaretroviral entry and contributes to evaluating the risk of zoonosis in xenotransplantation. Results Chimeras of the non-permissive murine PAR and the permissive HuPAR2 which scanned the entire molecule revealed that the first 135 amino acids of HuPAR2 are critical for PERV-A entry. Within this critical region eighteen single residue .