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Báo cáo y học: " HIV infection of non-dividing cells: a divisive problem"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " HIV infection of non-dividing cells: a divisive problem. | Retrovirology BioMed Central Review HIV infection of non-dividing cells a divisive problem Ariberto Fassati Open Access Address Wohl Virion Centre and MRC-UCL Centre for Medical Molecular Virology Division of Infection and Immunity University College London 46 Cleveland Street London W1T 4JF UK Email Ariberto Fassati - a.fassati@ucl.ac.uk Corresponding author Published 26 October 2006 Retrovirology 2006 3 74 doi 10.1186 1742-4690-3-74 Received 12 September 2006 Accepted 26 October 2006 This article is available from http www.retrovirology.Com content 3 1 74 2006 Fassati licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Understanding how lentiviruses can infect terminally differentiated non-dividing cells has proven a very complex and controversial problem. It is however a problem worth investigating for it is central to HIV-1 transmission and AIDS pathogenesis. Here I shall attempt to summarise what is our current understanding for HIV-1 infection of non-dividing cells. In some cases I shall also attempt to make sense of controversies in the field and advance one or two modest proposals. Background DNA viruses and some RNA viruses must access the nucleus to replicate. This is also the case for lentiviruses and several excellent reviews have been recently published on the subject 1-5 . The interior of the nucleus is separated from the cytoplasm by a double-layer membrane contiguous with the ER called the nuclear envelope NE 6 . Embedded in the nuclear envelope are nuclear pores which are channel-like macromolecules regulating access to the nucleus. In simple functional terms nuclear pores can be considered like selective filters that allow diffusion of ions and molecules smaller than 9 nm across the NE and facilitated