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Báo cáo y học: " influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients"

Available online http://ccforum.com/content/12/4/R101 Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients. | Available online http ccforum.eom content 1 2 4 R101 Research Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery major trauma and subarachnoid hemorrhage patients Mette M Berger1 Ludivine Soguel1 Alan Shenkin2 Jean-Pierre Revelly1 Christophe Pinget3 Malcolm Baines2 and René L Chioléro1 Open Access Department of Intensive Care Medicine Burns Centre University Hospital Centre Hospitalier Universitaire Vaudois CHUV Rue du Bugnon 46 CH-1011 Lausanne Switzerland 2Department of Clinical Chemistry Royal Liverpool University Hospital and University of Liverpool Liverpool UK 3Health Technology Assessment Unit CHUV Rue du Bugnon 46 CH-1011 Lausanne Switzerland Corresponding author Mette M Berger Mette.Berger@chuv.ch Received 17 Apr 2008 Revisions requested 14 May 2008 Revisions received 14 Jul 2008 Accepted 7 Aug 2008 Published 7 Aug 2008 Critical Care 2008 12 R101 doi 10.1186 cc6981 This article is online at http ccforum.com content 12 4 R1 01 2008 Berger et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Oxidative stress is involved in the development of secondary tissue damage and organ failure. Micronutrients contributing to the antioxidant AOX defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit ICU patients with conditions characterized by oxidative stress. Methods We conducted a prospective randomized doubleblind placebo-controlled single-center trial in patients admitted to a university hospital ICU with organ failure after complicated cardiac surgery major trauma or subarachnoid hemorrhage. Stratification .