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Báo cáo y học: " Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants | Retrovirology BioMed Central Research Open Access Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants Christophe Debacq1 Maria Teresa Sanchez Alcaraz1 Franck Mortreux2 Pierre Kerkhofs3 Richard Kettmann1 and Luc Willems 1 Address 1Molecular and cellular biology FUSAGx Gembloux Belgium 2Unité d Oncogenèse Virale CNRS UMR5537 Centre Léon Bérard Lyon France and 3Department of Virology Veterinary and Agrochemical Research Centre Uccle Belgium Email Christophe Debacq - debacq.c@fsagx.ac.be Maria Teresa Sanchez Alcaraz - sanchezalcaraz.m@fsagx.ac.be Franck Mortreux - MORTREUX@lyon.fnclcc.fr Pierre Kerkhofs - piker@var.fgov.be Richard Kettmann - kettmann.r@fsagx.ac.be Luc Willems - willems.l@fsagx.ac.be Corresponding author Published 05 October 2004 Received 23 June 2004 Accepted 05 October 2004 Retrovirology 2004 1 31 doi l0.ll86 l742-4690-1-31 This article is available from http www.retrovirology.cOm content 1 1 3 1 2004 Debacq et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The early stages consecutive to infection of sheep e.g. primo-infection by Bovine leukemia virus mutants are largely unknown. In order to better understand the mechanisms associated with this period we aimed at analyzing simultaneously three parameters B-lymphocytosis cell proliferation and viral replication. Results Sheep were experimentally infected either with a wild type BLV provirus or with selected mutants among which a virus harboring an optimalized LTR promoter with consensus cyclic AMP-responsive elements two deletants of the R3 or the G4 accessory genes and a fusion-deficient transmembrane recombinant. Seroconversion as revealed by the onset of an anti-viral antibody response .