Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions"

Không đóng trình duyệt đến khi xuất hiện nút TẢI XUỐNG

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions. | CLINICAL PROTEOMICS 10000000 1000000 100000 Down-regulation of kallikrein-related peptidase 5 KLK5 expression in breast cancer patients a biomarker for the differential diagnosis of breast lesions Avgeris et al. Avgeris et al. Clinical Proteomics 2011 8 5 http www.clinicalproteomicsjournal.Com content 8 1 5 31 May 2011 BioMed Central Avgeris et al. Clinical Proteomics 2011 8 5 http www.clinicalproteomicsjournal.eom content 8 1 5 CLINICAL PROTEOMICS RESEARCH Open Access Down-regulation of kallikrein-related peptidase 5 KLK5 expression in breast cancer patients a biomarker for the differential diagnosis of breast lesions Margaritis Avgeris1 Georgia Papachristopoulou1 2 Athanasios Polychronis2 and Andreas Scorilas1 Correspondence ascorilas@biol. uoa.gr department of Biochemistry and Molecular Biology University of Athens Panepistimiopolis 15701 Athens Greece Full list of author information is available at the end of the article Abstract Background Kallikrein-related peptidase 5 KLK5 is a secreted trypsin-like protease of the KLK family encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components as well as to activate several other KLK proteases triggering the stimulation of tissue microenvironment proteolytic cascades. Material and Methods KLK5 expression levels were quantified in 102 cancerous and benign breast tissue specimens obtained by randomly chosen patients using RT-qPCR assay. Subsequently advanced biostatistics were applied in order to analyze the KLK5 expression profile in the two patients cohorts and also to evaluate its clinical significance for the discrimination of breast tumors. Results A statistically significant p 0.001 down-regulation of the KLK5 expression levels were observed in the malignant specimens compared to the benign ones. Logistic regression and ROC curve analysis revealed the significant p 0.001 and the independent p 0.001 value of the KLK5 expression quantification for the discrimination of the .

TÀI LIỆU LIÊN QUAN

Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function"

Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase"

Báo cáo y học: "roteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis"

Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus"

Báo cáo y học: "Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis"

Báo cáo y học: " Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis"

Báo cáo y học: "Downregulation of CD94/NKG2A inhibitory receptors on cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts"

Báo cáo y học: "Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release"

Báo cáo y học: "Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathway"

Báo cáo y học: " Stimulation with Peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytes"
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.