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Báo cáo y học: "Protective role of statins against ventilator-induced lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Protective role of statins against ventilator-induced lung injury. | Siempos et al. Critical Care 2010 14 441 http ccforum.eom content 14 5 441 CRITICAL CARE LETTER L_ Protective role of statins against ventilator-induced lung injury lli-nir I Ciomr 2c1 DcilThThc mtori Hoc1 2 iCry112 The A K 1i2 t iii2l ic1 2 12 mA A ThThctThlThc A rmi2Thi2r ii Hic1 2 IliasiDiempos Petros Kopteiiues NikolaosAMailiatis al I dApUSLUlUsAII I Idydl ll db See related research by Muller et al. http ccforum.eom content 14 4 R143 We compliment Dr Muller and colleagues 1 for their experiment on the protective role of simvastatin against ventilator-induced lung injury VILI . Their results are in line with those of a relevant study published recently by our research team we also showed that pretreatment with statins specifically atorvastatin attenuates VILI 2 . By synthesizing the findings of the above contributions 1 2 one could make several points. First given that Muller and colleagues administered simvastatin 1 while we chose atorvastatin 2 it seems that the observed benefit is a class-specific rather than a drug-specific effect that is it may apply to the whole class of statins. Second the prevention of VILI by statins seems not to be species-specific indeed our colleagues employed mice 1 while we preferred rabbits 2 . Third while the first study used female animals 1 and the second study used male animals 2 there were no differences in the produced results thus statins seem to be useful for the prevention of VILI in both sexes. This observation is important given the ongoing interest in the possibility that drug responses may differ by sex 3 . Fourth by using different markers both studies noted that administration of statins reduced VILI-associated hyperpermeability 1 2 . Indeed the German group 1 used as a marker of lung permeability the human-serumalbumin bronchoalveolar lavage plasma ratio while we used both lung edema and ultrafiltration coefficient Kf c . Finally Muller and colleagues implemented a 6-hour model of injurious mechanical .