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Báo cáo y học: "Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages. | Research Open Access Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages Sylvain PradervandH Ý Mano R MauryaH and Shankar Subramaniam n Addresses Bioinformatics and Data Coordination Laboratory Alliance for Cellular Signaling San Diego Supercomputer Center University of California at San Diego Gilman Drive La Jolla CA 92093 USA. ỶDepartment of Bioengineering University of California at San Diego Gilman Drive La Jolla CA 92093 USA. Department of Chemistry and Biochemistry University of California at San Diego Gilman Drive La Jolla CA 92093 USA. H These authors contributed equally to this work. Correspondence Shankar Subramaniam. Email shankar@ucsd.edu Published 20 February 2006 Genome Biology 2006 7 RI I doi 10.1 I86 gb-2006-7-2-rII The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 2 RII Received 26 August 2005 Revised 25 November 2005 Accepted 18 January 2006 2006 Pradervand et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Release of immuno-regulatory cytokines and chemokines during inflammatory response is mediated by a complex signaling network. Multiple stimuli produce different signals that generate different cytokine responses. Current knowledge does not provide a complete picture of these signaling pathways. However using specific markers of signaling pathways such as signaling proteins it is possible to develop a coarse-grained network map that can help understand common regulatory modules for various cytokine responses and help differentiate between the causes of their release. Results Using a systematic profiling of signaling responses and cytokine release in RAW .