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Báo cáo y học: "Comparative genomics of Drosophila and human core promoters"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative genomics of Drosophila and human core promoters. | Research Open Access Comparative genomics of Drosophila and human core promoters Peter C FitzGerald David Sturgill Andrey Shyakhtenko Brian Oliver and Charles Vinson Addresses Genome Analysis Unit National Cancer Institute National Institutes of Health Bethesda MD 20892 USA. laboratory of Cellular and Developmental Biology National Institute of Diabetes and Digestive and Kidney National Institutes of Health Bethesda MD 20892 USA. Laboratory of Metabolism National Cancer Institute National Institutes of Health Bethesda MD 20892 USA. Correspondence CharlesVinson. Email vinsonc@dc37a.nci.nih.gov Published 7 July 2006 Genome Biology 2006 7 R53 doi 10.1 186 gb-2006-7-7-r53 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 7 R53 Received 22 March 2006 Revised 8 May 2006 Accepted 6 June 2006 2006 FitzGerald et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The core promoter region plays a critical role in the regulation of eukaryotic gene expression. We have determined the non-random distribution of DNA sequences relative to the transcriptional start site in Drosophila melanogaster promoters to identify sequences that may be biologically significant. We compare these results with those obtained for human promoters. Results We determined the distribution of all 65 536 octamer 8-mers DNA sequences in 10 914 Drosophila promoters and two sets of human promoters aligned relative to the transcriptional start site. In Drosophila 298 8-mers have highly significant p 1 X 10-16 non-random distributions peaking within 100 base-pairs of the transcriptional start site. These sequences were grouped into 15 DNA motifs. Ten motifs termed directional motifs