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Báo cáo y học: "Update of the Anopheles gambiae PEST genome assembly"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Update of the Anopheles gambiae PEST genome assembly. | Open Access Research Update of the Anopheles gambiae PEST genome assembly Maria V Sharakhova Martin P Hammond Neil F Lobo Jaroslaw Krzywinski Maria F Unger Maureen E Hillenmeyer Robert V Bruggner Ewan Birney and Frank H Collins Addresses Center for Global Health and Infectious Diseases University of Notre Dame Galvin Life Sciences Building Notre Dame IN 465560369 USA. Department of Entomology College of Agriculture and Life Science Virginia Polytechnic Institute and State University Blacksburg VA 24061-0319 USA. European Bioinformatics Institute EMBL-EBI Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK. Department of Biology University of Texas at Arlington Arlington TX 76019 USA. School of Medicine - IDP - Biomedical Informatics Stanford University Stanford CA 94305 USA. Correspondence Frank H Collins. Email frank@nd.edu Published 8 January 2007 Genome Biology 2007 8 R5 doi 10.1186 gb-2007-8-1-r5 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 1 R5 Received 26 July 2006 Revised 24 October 2006 Accepted 8 January 2007 2007 Sharakhova et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The genome of Anopheles gambiae the major vector of malaria was sequenced and assembled in 2002. This initial genome assembly and analysis made available to the scientific community was complicated by the presence of assembly issues such as scaffolds with no chromosomal location no sequence data for the Y chromosome haplotype polymorphisms resulting in two different genome assemblies in limited regions and contaminating bacterial DNA. Results Polytene chromosome in situ hybridization with cDNA clones was used to place 15 unmapped scaffolds .