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Báo cáo y học: "Diarrhea as a cause of mortality in a mouse model of infectious colitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Diarrhea as a cause of mortality in a mouse model of infectious colitis. | Open Access Research Diarrhea as a cause of mortality in a mouse model of infectious colitis Diana Borenshtein Rebecca C Fry Elizabeth B Groff Prashant R Nambiar Vincent J Carey James G Fox and David B Schauer Addresses Department of Biological Engineering Massachusetts Institute of Technology Massachusetts Avenue Cambridge MA 02139 USA. Center of Environmental Health Sciences Massachusetts Institute of Technology Massachusetts Avenue Cambridge MA 02139 USA. Division of Comparative Medicine Massachusetts Institute of Technology Massachusetts Avenue Cambridge MA 02139 USA. Harvard Medical School Longwood Avenue Boston MA 02115 USA. Current address Department of Environmental Sciences and Engineering The University of North Carolina at Chapel Hill Dauer Drive Chapel Hill NC 27599 USA. Current address Genzyme Corporation Mountain Road Framingham MA 01701 USA. Correspondence David B Schauer. Email schauer@mit.edu Published 4 August 2008 Received 26 October 2007 Genome Biology 2008 9 R122 doi 10.1186 gb-2008-9-8-r122 Revised 1 May.2008 gy g Accepted 4 August 2008 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 8 R122 2008 Borenshtein et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Comparative characterization of genome-wide transcriptional changes during infection can help elucidate the mechanisms underlying host susceptibility. In this study transcriptional profiling of the mouse colon was carried out in two cognate lines of mice that differ in their response to Citrobacter rodentium infection susceptible inbred FVB N and resistant outbred Swiss Webster mice. Gene expression in the distal colon was determined prior to infection and at