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Báo cáo khoa hoc:" Wnt expression is not correlated with β-catenin dysregulation in Dupuytren's Disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Wnt expression is not correlated with β-catenin dysregulation in Dupuytren's Disease | Journal of Negative Results in BioMedicine BioMed Central Research Wnt expression is not correlated with p-catenin dysregulation in Dupuytren s Disease David B O Gorman1 2 Yan Wu1 Shannon Seney1 Rebecca D Zhu1 and Bing Siang Gan 1 2 3 4 Open Access Address 1Cell and Molecular Biology Laboratory Hand and Upper Limb Centre Lawson Health Research Institute St. Joseph s Health Centre London Ontario Canada 2Department of Surgery University of Western Ontario London Ontario Canada 3Department of Physiology and Pharmacology University of Western Ontario London Ontario Canada and 4Department of Medical Biophysics University of Western Ontario London Ontario Canada Email David B O Gorman - dogorman@uwo.ca Yan Wu - yan.wu@sjhc.london.on.ca Shannon Seney - shannon.seney@lhrionhealth.ca Rebecca D Zhu - rebecca@flynature.com Bing Siang Gan - bgan@uwo.ca Corresponding author Published 30 August 2006 Received 20 February 2006 Journal of Negative Results in BioMedicine 2006 5 13 doi l0.H86Z 1477-5751-5-13 Accepted 30 August 2006 This article is available from http www.jnrbm.cOm content 5 1 13 2006 O Gorman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Dupuytren s contracture or disease DD is a fibro-proliferative disease of the hand that results in finger flexion contractures. Increased cellular P-catenin levels have been identified as characteristic of this disease. As Wnts are the most widely recognized upstream regulators of cellular P-catenin accumulation we have examined Wnt gene expression in surgical specimens and in DD-derived primary cell cultures grown in two-dimensional monolayer culture or in threedimensional FPCL .