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Báo cáo y học: "The angiogenesis inhibitor protease-activated kringles 1–5 reduces the severity of murine collagen-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The angiogenesis inhibitor protease-activated kringles 1–5 reduces the severity of murine collagen-induced arthritis. | Arthritis Research and Therapy Vol 5 No 1 Sumariwalla et al. Research article Open Access The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis Percy F Sumariwalla1 Yihai Cao2 Hua-Lin Wu3 Marc Feldmann1 and Ewa M Paleolog1 Kennedy Institute of Rheumatology Division Faculty of Medicine Imperial College of Science Technology and Medicine London UK 2Laboratory of Angiogenesis Research Microbiology and Tumor Biology Center Karolinska Institute Stockholm Sweden 3Department of Biochemistry National Cheng Kung University Medical College Taiwan Republic of China Corresponding author Dr Ewa Paleolog e-mail e.paleolog@ic.ac.uk Received 10 July 2002 Revisions received 27 September 2002 Accepted 2 October 2002 Published 31 October 2002 Arthritis Res Ther 2003 5 R32-R39 DOI 10.1186 ar608 2003 Sumariwalla et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract During rheumatoid arthritis there is enlargement and increased cellularity of the synovial lining of joints before invasion by the synovium of the underlying cartilage and bone. This increased tissue mass requires a network of blood vessels to supply nutrients and oxygen. Disruption of synovial angiogenesis is thus a desirable aim of antiarthritic therapies. Protease-activated kringles 1-5 K1-5 is an angiogenesis inhibitor related to angiostatin. In common with angiostatin K1-5 contains the first four kringle domains of plasminogen but also encompasses the kringle 5 domain which confers enhanced antiangiogenic activity when compared with angiostatin. The purpose of the present study was to assess the effect on murine arthritis of K1-5. Arthritis was induced in DBA 1 mice by a single injection of bovine collagen. .