Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition. | Available online http content 9 6 R1 27 Research article Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis potential role for angiogenesis inhibition John Bainbridge1 Leigh Madden1 David Essex1 Michael Binks3 Rajneesh Malhotra3 and Ewa M Paleolog1 2 Kennedy Institute of Rheumatology Faculty of Medicine Imperial College London 1 Aspenlea Road London W6 8LH UK 2Division of Surgery Oncology Reproductive Biology Anaesthetics Faculty of Medicine Imperial College 1 Aspenlea Road London London W6 8LH UK 3II CEDD GSK Medicines Research Centre Gunnels Wood Road Stevenage SG1 2NY UK Corresponding author Ewa M Paleolog Received 18 Jul 2007 Revisions requested 19 Sep 2007 Revisions received 24 Oct 2007 Accepted 11 Dec 2007 Published 11 Dec 2007 Arthritis Research Therapy 2007 9 R127 doi ar2340 This article is online at http content 9 6 R1 27 2007 Bainbridge et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The enzyme methionine aminopeptidase-2 MetAP-2 is thought to play an important function in human endothelial cell proliferation and as such provides a valuable target in both inflammation and cancer. Rheumatoid arthritis RA is a chronic inflammatory disease associated with increased synovial vascularity and hence is a potential therapeutic target for angiogenesis inhibitors. We examined the use of PPI-2458 a selective non-reversible inhibitor of MetAP-2 in disease models of RA namely acute and chronic collagen-induced arthritis CIA in mice. Whilst acute CIA is a monophasic disease CIA induced with murine collagen type II manifests as a chronic relapsing arthritis and mimics more closely the disease .
