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Báo cáo y học: "Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations. | Available online http arthritis-research.eom content 11 5 R147 Research article Plasma cytokine profiles in systemic sclerosis associations with autoantibody subsets and clinical manifestations Pravitt Gourh Frank C Arnett Shervin Assassi Filemon K Tan Mei Huang Laura Diekman Maureen D Mayes John D Reveille and Sandeep K Agarwal Division of Rheumatology and Clinical Immunogenetics Department of Internal Medicine University of Texas Health Science Center at Houston 6431 Fannin M.S.B. 5.278 Houston TX 77030 USA Corresponding author Sandeep K Agarwal Sandeep.K.Agarwal@uth.tmc.edu Received 8 Jun 2009 Revisions requested 7 Jul 2009 Revisions received 19 Aug 2009 Accepted 2 Oct 2009 Published 2 Oct 2009 Arthritis Research Therapy 2009 11 R147 doi 10.1186 ar2821 This article is online at http arthritis-research.com content 11 5 R147 2009 Gourh et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Systemic sclerosis SSc scleroderma is a complex autoimmune disease that clinically manifests as progressive fibrosis of the skin and internal organs. Anticentromere antibodies ACAs anti-topoisomerase antibodies ATAs and anti-RNA polymerase III antibodies ARAs are three mutually exclusive SSc-associated autoantibodies that correlate with distinct clinical subsets characterized by extent of cutaneous involvement and pattern of organ involvement. The current report sought to determine whether plasma cytokine profiles differ in SSc patients grouped according to these SSc-associated autoantibody subsets. Methods Plasma from 444 SSc patients and 216 healthy controls was obtained from the Scleroderma Family Registry and University of Texas Rheumatology Division. Patients were classified according to the .