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Báo cáo y học: "Surfactant Protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Surfactant Protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses. | Respiratory Research BioMed Central Research Open Access Surfactant Protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses Seth Thomas Scanlon1 Tatyana Milovanova2 Sonja Kierstein1 Yang Cao1 Elena N Atochina1 Yaniv Tomer1 Scott J Russo1 Michael F Beers1 and Angela Haczku 1 Address 1Pulmonary Allergy and Critical Care Division Department of Medicine University of Pennsylvania School of Medicine Philadelphia USA and institute for Environmental Medicine University of Pennsylvania School of Medicine Philadelphia USA Email Seth Thomas Scanlon - sscanlon@uchicago.edu Tatyana Milovanova - tmilovan@mail.med.upenn.edu Sonja Kierstein - skierstein@mac.com Yang Cao - yc6@post.queensu.ca Elena N Atochina - EAtochina@stelex.com YanivTomer - ytomer@usa.net Scott J Russo - sjrusso@mail.med.upenn.edu Michael F Beers - mfbeers@mail.med.upenn.edu Angela Haczku - haczku@mail.med.upenn.edu Corresponding author Published 24 August 2005 Received 30 November 2004 Respiratory Research 2005 6 97 doi 10.1186 1465-9921 -6-97 Accepted 24 August 2005 This article is available from http respiratory-research.cOm content 6 1 97 2005 Scanlon et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The pulmonary surfactant protein SP -A has potent immunomodulatory activities but its role and regulation during allergic airway inflammation is unknown. Methods We studied changes in SP-A expression in the bronchoalveolar lavage BAL using a murine model of single Aspergillus fumigatus Af challenge of sensitized animals. Results SP-A protein levels in the BAL fluid showed a rapid transient decline that reached the lowest values 25 of controls 12 h after intranasal Af provocation of sensitized mice. Decrease of SP-A was .