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Báo cáo y học: "Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. | Available online http ccforum.eom content 10 2 R60 Research Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients Andrew Rhodes1 Stephen J Wort1 Helen Thomas2 Paul Collinson2 and E David Bennett1 intensive Care Unit St Georges s Hospital London UK 2Department of Chemical Pathology St Georges s Hospital London UK Corresponding author Andrew Rhodes arhodes@sghms.ac.uk Received 30 Nov 2005 Revisions requested 6 Jan 2006 Revisions received 13 Mar 2006 Accepted 16 Mar 2006 Published 13 Apr 2006 Critical Care 2006 10 R60 doi 10.1186 cc4894 This article is online at http ccforum.com content 10 2 R60 2006 Rhodes et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Risk stratification of severely ill patients remains problematic resulting in increased interest in potential circulating markers such as cytokines procalcitonin and brain natriuretic peptide. Recent reports have indicated the usefulness of plasma DNA as a prognostic marker in various disease states such as trauma myocardial infarction and stroke. The present study assesses the significance of raised levels of plasma DNA on admission to the intensive care unit ICU in terms of its ability to predict disease severity or prognosis. Methods Fifty-two consecutive patients were studied in a general ICU. Blood samples were taken on admission and were stored for further analysis. Plasma DNA levels were estimated by a PCR method using primers for the human p-haemoglobin gene. Results Sixteen of the 52 patients investigated died within 3 months of sampling. Nineteen of the 52 patients developed either severe sepsis or septic shock. Plasma DNA was higher in ICU patients than in healthy controls and was also .