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Textbook of Interventional Cardiovascular Pharmacology phần 8

Đại diện hematoxylin và eosin mặt cắt ngang dính ABC từ (A) không bị thương, (B) chiếc xe được điều trị, và (C) động mạch paclitaxel được điều trị, bị thương chuột cảnh. X240. Nguồn: Từ Tài liệu tham khảo. 47. | 444 Clinical trials in cellular therapy Table 1 Clinical trials of cellular therapy in acute myocardial infarction Trial NN Cell dose Delivery Time post MI days Outcome Strauer 10 Tx 10 Ctrl 28 million IC 5-9 Decreased infarct size improved perfusion improved wall motion TOPCARE-AMI 59 Tx 11 Ctrl 200 million IC 4 Increased EF coronary flow regional wall motion and decreased infarct size Fernander-Aviles 20 Tx 13 Ctrl 78 million IC 14 Increased EF and wall motion BOOST 30 Tx and 30 Ctrl 2.5 billion of nucleated bone marrow cells IC 6 Increased EF and regional wall motion no change in infarct size Kuethe 5 Tx 40 million IC 6 No effect REPAIR-AMI 204 236 million IC 4 Increased EF 5 and less repeat revascularization ASTAMI 100 IC 5-8 No effect Abbreviations ASTAMI autologous stem cell transplantation in acute myocardial infarction BOOST bone marrow transfer to enhance ST-elevation infarct regeneration Ctrl control EF ejection fraction IC intracoronary N number Tx treated REPAIR-AMI reinfusion of enriched progenitor cells and infarct remodeling in acute myocardial infarction TOPCARE-AMI transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction. who were not candidates for traditional revascularization owing to the diffuse nature of their disease 38 39 . The studies failed to account for a strong placebo effect observed in this group and the follow-up studies failed to show efficacy 40 . The idea of using ABMSCs as potential sources of angiogenic factors has now been tested in several trials 41-44 . Given that patients are not candidates for revascularization injection of the cells has to be accomplished via a transendocardial route with the guidance of electromechanical mapping EMM using a NOGA catheter or other intramyocardial injection catheters. The first feasibility study to assess this new methodology enrolled eight patients with angina refractory to medical therapy 42 . They were assessed with functional cardiac MRI at three .