Peste des petits ruminants (PPRV) is a highly contagious transboundary viral disease of small ruminants with widespread distribution and poorly characterized molecular pathogenesis. The present study aimed at delineating the role of NF-kB signalling pathway during PPRV infection in the in-vitro system. For this the gene expression of three major regulatory proteins of NF-kB pathway viz. IKBα, IKKβ and RelA were analysed in the PPRV infected and mock infected Vero cells as a function of time using SYBR-green based one-step RT-qPCR. The results genes revealed downregulation of IKBα gene and upregulation of RelA and IKKβ genes in the PPRV infected group as against mock infected during initial hours of infection. | Expression of RelA, IKBα and IKKβ Genes in peste des petits ruminants virus infected cells
