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báo cáo khoa học: "Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells | BioMed Central Journal of Hematology Oncology Research Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells relevance for detection of circulating tumor cells Fanglei You11 Lisa A Roberts12 S Peter Kang4 Raquel A Nunes1 Cinara Dias1 J Dirk Iglehart1 3 Natalie A Solomon 2 Paula N Friedman2 and Lyndsay N Harris 4 Address Department of Cancer biology Adult Oncology Dana-Farber Cancer Institute Boston MA 02115 USA 2Abbott Molecular Inc. 1300 E. Touhy Avenue Des Plaines IL 60018 USA 3Department of Surgery Brigham and Women s Hospital Boston MA 02115 USA and 4Section of Medical Oncology Yale University School of Medicine Yale Cancer Center 333 Cedar Street New Haven Connecticut 06520 USA Email Fanglei You - fangleiyou@yahoo.com Lisa A Roberts - Lisa.Roberts@abbott.com S Peter Kang - soonmo.kang@yale.edu Raquel A Nunes - Raquelnunes2@yahoo.com Cinara Dias - diascinara@yahoo.com J Dirk Iglehart - Jiglehart@partnes.org Natalie A Solomon - natalie.solomon@abbott.com Paula N Friedman - pfriedman@uchicago.edu Lyndsay N Harris - lyndsay.harris@yale.edu Corresponding authors fEqual contributors Open Access Published 28 May 2008 Received 25 April 2008 Journal of Hematology Oncology 2008 1 2 doi 10.1186 1756-8722-1 -2 Accepted 28 May 2008 This article is available from http www.jhoonline.Org content 1 1 2 2008 You et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Detection of circulating tumor cells CTC in the blood of cancer patients may have prognostic and predictive significance. However background expression of tumor specific markers in peripheral blood mononuclear cells PBMC may confound these studies. The goal of this study was to identify the origin of Cytokeratin 19 CK19 and .