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báo cáo khoa học: "Electrophoresis in nanochannels: brief review and speculation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Electrophoresis in nanochannels: brief review and speculation | Journal of Nanobiotechnology BioMed Central Open Access Review Electrophoresis in nanochannels brief review and speculation Fabio Baldessari and Juan G Santiago Address Department of Mechanical Engineering Stanford University Stanford CA USA Email Fabio Baldessari - fabiob1@stanford.edu Juan G Santiago - juan.santiago@stanford.edu Corresponding author Published 20 November 2006 Received 14 June 2006 Accepted 20 November 2006 Journal of Nanobiotechnology 2006 4 12 doi l0.l I86 I477-3I55-4-I2 This article is available from http www.jnanobiotechnology.com content 4 1 12 2006 Baldessari and Santiago licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The relevant physical phenomena that dominate electrophoretic transport of ions and macromolecules within long thin nanochannels are reviewed and a few papers relevant to the discussion are cited. Sample ion transport through nanochannels is largely a function of their interaction with electric double layer. For small ions this coupling includes the net effect of the external applied field the internal field of the double layer and the non-uniform velocity of the liquid. Adsorption desorption kinetics and the effects of surface roughness may also be important in nanochannel electrophoresis. For macromolecules the resulting motion is more complex as there is further coupling via steric interactions and perhaps polarization effects. These complex interactions and coupled physics represent a valuable opportunity for novel electrophoretic and chromatographic separations. Background Recent advances in nano-scale fabrication techniques allow for novel experimentation of the role of fluidic systems in analysis detection and separation of chemical and biological agents 1-9 . Electric