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báo cáo khoa học: " Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties | Journal of Nanobiotechnology BioMed Central Research Hydrophobic silver nanoparticles trapped in lipid bilayers Size distribution bilayer phase behavior and optical properties Geoffrey D Bothun Open Access Address Department of Chemical Engineering University of Rhode Island Kingston RI 02881 USA Email Geoffrey D Bothun - bothun@egr.uri.edu Published 12 November 2008 Received 2 July 2008 I. rr Accepted 12 November 2008 Journal of Nanobiotechnology 2008 6 13 doi 10.1186 1477-3155-6-13 This article is available from http www.jnanobiotechnology.com content 6 1 13 2008 Bothun licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lipid-based dispersion of nanoparticles provides a biologically inspired route to designing therapeutic agents and a means of reducing nanoparticle toxicity. Little is currently known on how the presence of nanoparticles influences lipid vesicle stability and bilayer phase behavior. In this work the formation of aqueous lipid nanoparticle assemblies LNAs consisting of hydrophobic silver-decanethiol particles 5.7 1.8 nm embedded within 1 2-dipalmitoyl-sn-glycero-3-phosphocholine DPPC bilayers is demonstrated as a function of the DPPC Ag nanoparticle AgNP ratio. The effect of nanoparticle loading on the size distribution bilayer phase behavior and bilayer fluidity is determined. Concomitantly the effect of bilayer incorporation on the optical properties of the AgNPs is also examined. Results The dispersions were stable at 50 C where the bilayers existed in a liquid crystalline state but phase separated at 25 C where the bilayers were in a gel state consistent with vesicle aggregation below the lipid melting temperature. Formation of bilayer-embedded nanoparticles was confirmed by .