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báo cáo khoa học: "Nanofibers and nanoparticles from the insectcapturing adhesive of the Sundew (Drosera) for cell attachment"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Nanofibers and nanoparticles from the insectcapturing adhesive of the Sundew (Drosera) for cell attachment | Zhang et al. Journal of Nanobiotechnology 2010 8 20 http www.jnanobiotechnology.eom content 8 1 20 JOURNAL OF NANOBIOTECHNOLOGY RESEARCH Open Access Nanofibers and nanoparticles from the insectcapturing adhesive of the Sundew Drosera for cell attachment 1 f 1f I 1 f 2f 13 1 4 Mingjun Zhang Scott C Lenaghan Lijin Xia Lixin Dong Wei He William R Henson Xudong Fan Abstract Background The search for naturally occurring nanocomposites with diverse properties for tissue engineering has been a major interest for biomaterial research. In this study we investigated a nanofiber and nanoparticle based nanocomposite secreted from an insect-capturing plant the Sundew for cell attachment. The adhesive nanocomposite has demonstrated high biocompatibility and is ready to be used with minimal preparation. Results Atomic force microscopy AFM conducted on the adhesive from three species of Sundew found that a network of nanofibers and nanoparticles with various sizes existed independent of the coated surface. AFM and light microscopy confirmed that the pattern of nanofibers corresponded to Alcian Blue staining for polysaccharide. Transmission electron microscopy identified a low abundance of nanoparticles in different pattern form AFM observations. In addition energy-dispersive X-ray spectroscopy revealed the presence of Ca Mg and Cl common components of biological salts. Study of the material properties of the adhesive yielded high viscoelasticity from the liquid adhesive with reduced elasticity observed in the dried adhesive. The ability of PC12 neuron-like cells to attach and grow on the network of nanofibers created from the dried adhesive demonstrated the potential of this network to be used in tissue engineering and other biomedical applications. Conclusions This discovery demonstrates how a naturally occurring nanofiber and nanoparticle based nanocomposite from the adhesive of Sundew can be used for tissue engineering and opens the possibility for further examination of .