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báo cáo khoa học: "Hemolytic anemia due to acute cytomegalovirus infection in an immunocompetent adult: a case report and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hemolytic anemia due to acute cytomegalovirus infection in an immunocompetent adult: a case report and review of the literature | Taglietti et al. Journal of Medical Case Reports 2010 4 334 http www.jmedicalcasereports.eom content 4 1 334 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Hemolytic anemia due to acute cytomegalovirus infection in an immunocompetent adult a case report and review of the literature Fabrizio Taglietti Cecilia M Drapeau Elisabetta Grilli Alessandro Capone Pasquale Noto Simone Topino Nicola Petrosillo Abstract Introduction Cytomegalovirus is a common virus responsible for a wide range of clinical manifestations. Hemolysis is a rare but potentially life-threatening complication of cytomegalovirus infection described mostly in immunocompromised patients the pathogenesis of which is still unclear. We performed a review of the literature regarding cases of hemolytic anemia during acute cytomegalovirus infection in apparently immunocompetent individuals. We searched for relevant articles in PubMed for the period of 1980 through 2008. Case presentation We describe a case of Coombs-negative hemolytic anemia in a 44-year-old Caucasian immunocompetent man with acute cytomegalovirus infection. Conclusion Clinicians should consider cytomegalovirus infection in the differential diagnosis of hemolytic anemia in immunocompetent adults. Possible therapeutic options include antiviral therapy and steroids although the best treatment strategy is still controversial. Introduction Cytomegalovirus CMV is a common viral agent responsible for a wide range of clinical manifestations that vary according to the immunologic status of the patient. In the immunocompetent adult patient primary CMV infection is generally asymptomatic or occurs as a mononucleosis-like self-limited syndrome. In immunocompromised patients CMV infection can lead to severe clinical manifestations related to direct viral cytotoxic effect on specific organs and tissues gastrointestinal tract central nervous system retina respiratory tract and hematopoietic system . In patients with transplants CMV is .