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báo cáo khoa học: "Long-term survival of a woman with well differentiated papillary mesothelioma of the peritoneum: a case report and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Long-term survival of a woman with well differentiated papillary mesothelioma of the peritoneum: a case report and review of the literature | Clarke and Helft Journal of Medical Case Reports 2010 4 346 http www.jmedicalcasereports.eom content 4 1 346 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Long-term survival of a woman with well differentiated papillary mesothelioma of the peritoneum a case report and review of the literature Jeffrey M Clarke1 Paul Helft2 Abstract Introduction Well-differentiated papillary mesothelioma of the peritoneum WDPMP is a rare subtype of epitheloid mesothelioma which is usually seen in young women. WDPMP is generally considered of low malignant potential however the long-term nature of the tumor remains poorly defined. Case presentation We describe the long-term follow-up of a 60-year-old woman of West African descent who has survived 24 years with WDPMP after receiving extensive local and systemic adjuvant chemotherapy. Her clinical course has included three exploratory laparotomies with intraperitoneal and intravenous chemotherapy over two decades. Her course was complicated by anthracycline-induced cardiomyopathy for which she underwent an orthotopic heart transplant. Our patient is alive with stable radiological evidence of peritoneal disease and continues to suffer from chronic abdominal pain. Conclusion No consensus exists regarding optimal treatment strategies for WDPMP. However given the low malignant potential of the tumor careful consideration should be made before proceeding with aggressive interventions. Further long-term follow-up reports are required to fully characterize this tumor. Introduction Mesothelioma is an uncommon neoplasm which originates from the mesothelial lining of the pleura pericardium peritoneum and tunica vaginalis 1 2 . Malignant peritoneal mesothelioma MPM makes up approximately 10 to 20 of all cases of mesothelioma 2 . MPM is an aggressive tumor typically associated with asbestos exposure and afflicts mainly men in the fifth to sixth decades of life 2 3 . In contrast well-differentiated papillary mesothelioma of the .