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báo cáo khoa học: "Long-term misuse of zopiclone in an alcohol dependent woman with a history of anorexia nervosa: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Long-term misuse of zopiclone in an alcohol dependent woman with a history of anorexia nervosa: a case report | Morinan and Keaney Journal of Medical Case Reports 2010 4 403 http www.jmedicalcasereports.eom content 4 1 403 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Long-term misuse of zopiclone in an alcohol dependent woman with a history of anorexia nervosa a case report Alun Morinan Francis Keaney Abstract Introduction The Z-drugs zaleplon zopiclone and zolpidem are short-acting hypnotics which act at the same receptor as the benzodiazepines but seemingly without the potential for misuse and the development of dependence of the older benzodiazepines. However with increased prescribing of Z-drugs reports of misuse and possible dependence began to appear in the literature particularly in people with a history of substance misuse and comorbid psychiatric illness. Here we report the case of a woman with a history of chronic zopiclone use and anorexia nervosa admitted for alcohol detoxification. Case presentation A 31-year old Caucasian British woman with a history of long-term zopiclone use and anorexia nervosa was admitted as an inpatient for a ten-day alcohol detoxification. Her weekly four days out of seven intake of alcohol was 180 units and her daily intake of zopiclone 30 mg. Apart from a short period five years ago she had been taking zopiclone for 13 years at daily doses of up to 90 mg. She admitted to using on top of her prescribed medication purchasing extra tablets from friends or receiving them gratis from her partner. After detoxification from alcohol and zopiclone she was prescribed diazepam which she found ineffectual and voiced her intention of returning to zopiclone on leaving the hospital. Conclusion Zopiclone is generally regarded as safer than benzodiazepines however this particular individual who was using high doses of zopiclone over many years may provide further evidence of a risk of dependency when this drug is prescribed for substance users with a comorbid psychiatric illness. Introduction Insomnia is a subjective experience of poor or .