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Báo cáo khoa hoc:" Oxaliplatin neurotoxicity – no general ion channel surface-charge effect"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Oxaliplatin neurotoxicity – no general ion channel surface-charge effect | Journal of Negative Results in BioMedicine BioMed Central Open Access Oxaliplatin neurotoxicity - no general ion channel surface-charge effect Amir Broomand1 Elin Jerremalm 2 Jeffrey Yachnin3 Hans Ehrsson2 and Fredrik Elinder1 Address Department of Clinical and Experimental Medicine Division of Cell Biology Linkõping University Linkõping Sweden 2Department of Oncology-Pathology Karolinska Institutet and Karolinska Pharmacy Karolinska University Hospital Solna Stockholm Sweden and 3Department of Oncology University Hospital Uppsala Uppsala Sweden Email Amir Broomand - amibr@ibk.liu.se Elin Jerremalm - elin.jerremalm@telia.com Jeffrey Yachnin - jeffrey.yachnin@akademiska.se Hans Ehrsson - hans.ehrsson@apoteket.se Fredrik Elinder - fredrik.elinder@liu.se Corresponding author Published 12 January 2009 Received 4 April 2008 Journal ofNegative Results in BioMedicine 2009 8 2 doi 10.1186 1477-5751-8-2 Accepted 12 January 2009 This article is available from http www.jnrbm.cOm content 8 1 2 2009 Broomand et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Oxaliplatin is a platinum-based chemotherapeutic drug. Neurotoxicity is the doselimiting side effect. Previous investigations have reported that acute neurotoxicity could be mediated via voltage-gated ion channels. A possible mechanism for some of the effects is a modification of surface charges around the ion channel either because of chelation of extracellular Ca2 or because of binding of a charged biotransformation product of oxaliplatin to the channel. To elucidate the molecular mechanism we investigated the effects of oxaliplatin and its chloride complex Pt dach oxCl - on the voltage-gated Shaker K channel expressed in Xenopus oocytes. The recordings were