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Báo cáo khoa hoc:" Multicentric Castleman's disease: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Multicentric Castleman's disease: a case report | Journal of Medical Case Reports BioMed Central Case report Multicentric Castleman s disease a case report Brian F Menezes 1 Rosemary Morgan2 and Mohammed Azad2 Open Access Address department of Medicine University Hospital Aintree Liverpool L9 7AL UK and directorate of Medicine for the Elderly Arrowe Park Hospital Wirral CH49 5PE UK Email Brian F Menezes - franmenezes77@yahoo.co.uk Rosemary Morgan - rosemary.morgan@whnt.nhs.uk Mohammed Azad - mohammed.azad@whnt.nhs.uk Corresponding author Published 5 September 2007 Received 14 June 2007 _ . - - J.IA I 10 -7 I -7rt Accepted 5 September 2007 Journal of Medical Case Reports 2007 1 78 doi 10.1186 1752-1947-1-78 This article is available from http www.jmedicalcasereports.cOm content 1 1 78 2007 Menezes et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Castleman s disease is a clinicopathological entity associated with lymphoproliferation. We report a case of a 71 year old gentleman who was initially clinically suspected to have lymphoma owing to clinical features at presentation but was later histologically confirmed to have Castleman s disease. This case report underlines the importance of definitive histological diagnosis in patients with lympadenopathic presentation associated with systemic symptoms and the distinctiveness of multicentric Castleman s disease from malignant lymphoma. In this report we also attempt to provide new insight through the review of medical literature into the clinical features pathogenesis diagnosis and treatment of this rare and relatively benign disorder. Background Castleman s disease CD is a heterogeneous group of lymphoproliferative disorders of uncertain cause 1 presenting with lymphadenopathy. It is histologically and .