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báo cáo khoa học:" Deriving health state utilities for the numerical pain rating scale"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Deriving health state utilities for the numerical pain rating scale | Dixon et al. Health and Quality of Life Outcomes 2011 9 96 http www.hqlo.eom content 9 1 96 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Deriving health state utilities for the numerical pain rating scale Simon Dixon 1 Chris D Poole2 Isaac Odeyemi3 Peny Retsa3 Colette Chambers3 and Craig J Currie4 Abstract Background The use of patient reported outcome measures within cost-effectiveness analysis has become commonplace. However specific measures are required that produce values referred to as utilities that are capable of generating quality adjusted life years. One such measure - the EQ-5D - has come under criticism due to the inherent limitations of its three-level response scales. In evaluations of chronic pain the numerical pain rating scale NPRS which has eleven levels is routinely used which has a greater measurement range but which can not be used in cost-effetiveness analyses. This study derived utility values for a series of EQ-5D health states that replace the pain dimensions with the NPRS thereby allowing a potentially greater range of pain intensities to be captured and included in economic analyses. Methods Interviews were undertaken with 100 member of the general population. Health state valuations were elicited using the time trade-off approach with a ten year time horizon. Additionally respondents were asked where the EQ-5D response scale descriptors of moderate and extreme pain lay on the 11-point NPRS scale. Results 625 valuations were undertaken across the study sample with the crude mean health state utilities showing a negative non-linear relationship with respect to increasing pain intensity. Relative to a NPRS of zero NPRS0 the successive pain levels NPRS1-10 had mean decrements in utility of 0.034 0.043 0.061 0.121 0.144 0.252 0.404 0.575 0.771 and 0.793 respectively. When respondents were asked to mark on the NPRS scale the EQ-5D pain descriptors of moderate and extreme pain the median responses were 4 and 8 respectively. .