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Báo cáo khoa học: "Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection | Virology Journal BioMed Central Open Access Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection Rhonda D Cardin 1 Fernando J Bravo1 Andrea P Sewell1 James Cummins2 Louis Flamand3 Jean-Marc Juteau4 David I Bernstein1 and Andrew Vaillant 4 Address division of Infectious Diseases Cincinnati Children s Hospital Medical Center University of Cincinnati Cincinnati Ohio USA 2Southern Research Institute 431 Aviation Way Frederick Maryland 21701 USA 3Rheumatology and Immunology Research Center CHUQ Research Center and Faculty of Medicine Laval University Quebec Canada and 4REPLICor Inc 500 Blvd Cartier West Suite 135 Laval Quebec H7V 5B7 Canada Email Rhonda D Cardin - rhonda.cardin@cchmc.org Fernando J Bravo - fernando.brave@cchmc.org Andrea P Sewell - apsewell81@hotmail.com James Cummins - cummins@sri.org Louis Flamand - louis.flamand@crchul.ulaval.ca JeanMarc Juteau - jmjuteau@gmail.com David I Bernstein - david.bernstein@cchmc.org Andrew Vaillant - availlant@replicor.com Corresponding authors Published 2 December 2009 Received 24 August 2009 Accepted 2 December 2009 Virologyjournal 2009 6 214 doi 10.1186 1743-422X-6-214 This article is available from http www.virologyj.cOm content 6 1 214 2009 Cardin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Phosphorothioated oligonucleotides PS-ONs have a sequence-independent broad spectrum antiviral activity as amphipathic polymers APs and exhibit potent in vitro antiviral activity against a broad spectrum of herpesviruses HSV-I HSV-2 HCMV VZV EBV and HHV-6A B and in vivo activity in a murine microbiocide model of genital HSV-2 infection. The activity of these agents against animal cytomegalovirus CMV infections in