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Báo cáo khoa học: "Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves | J. Vet. Sci. 2007 8 4 357-360 JOURNAL OF Veterinary Science Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves Vinod K. Dumka Department of Pharmacology and Toxicology College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University Ludhiana-141004 India The disposition kinetics of levofloxacin was investigated in six male crossbred calves following single intravenous administration at a dose of 4 mg kg body weight into the jugular vein subsequent to a single intramuscular injection of paracetamol 50 mg kg . At 1 min after the injection of levofloxacin the concentration of levofloxacin in plasma was 17.2 0.36 gg ml which rapidly declined to 6.39 0.16 gg ml at 10 min. The drug level above the MIC90 in plasma was detected for up to 10 h. Levofloxacin was rapidly distributed from blood to the tissue compartment as evidenced by the high values of the distribution coefficient a 17.3 1.65 h and the ratio of K12 K21 1.83 0.12 . The values of AUC and Vdarea were 12.7 0.12 gg.h ml and 0.63 0.01 l kg. The high ratio of the AUC MIC 126.9 1.18 obtained in this study indicated the excellent antibacterial activity of levofloxacin in calves. The elimination half-life MRT and total body clearance were 1.38 0.01 h 1.88 0.01 h and 0.32 0.003 l kg h respectively. Based on the pharmacokinetic parameters an appropriate intravenous dosage regimen for levofloxacin would be 5 mg kg repeated at 24 h intervals when prescribed with paracetamol in calves. Key words calves disposition dosage levofloxacin paracetamol Introduction Under field conditions the management of bacterial infections with the administration of antibacterial with analgesic agents is standard treatment. Fluoroquinolones are known to interact with non-steroidal anti-inflammatory drugs at pharmacokinetic levels 20 . Fluoroquinolone resistance relates directly to the human and veterinary usage and emerging bacterial resistance poses