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Báo cáo khoa học: "Cerebellar vermian hypoplasia in a Cocker Spaniel"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Cerebellar vermian hypoplasia in a Cocker Spaniel | J. Vet. Sci. 2008 9 2 215-217 JOURNAL OF Case Report Veterinary Science Cerebellar vermian hypoplasia in a Cocker Spaniel Ji-Hey Lim1 Dae-Yong Kim2 Jung-hee Yoon3 Wan Hee Kim1 Oh-kyeong Kweon1 A Departments of Veterinary Surgery 2Pathology and 3Radiology College of Veterinary Medicine Seoul National University Seoul 151-742 Korea An eight-week-old female Cocker Spaniel was presented with ataxia dysmetria and intention tremor. At 16 weeks the clinical signs did not progress. Investigation including imaging studies of the skull and cerebrospinal fluid analysis were performed. The computed tomography revealed a cyst-like dilation at the level of the fourth ventricle associated with vermal defect in the cerebellum. After euthanasia a cerebellar hypoplasia with vermal defect was identified on necropsy. A polymerase chain reaction amplification of cerebellar tissue revealed the absence of an in utero parvoviral infection. Therefore the cerebellar hypoplasia in this puppy was consistent with diagnosis of primary cerebellar malformation comparable to Dandy-Walker syndrome in humans. Keywoids cerebellar hypoplasia dog vermian defect Congenital cerebellar abnormalities have been described in many species. Cerebellar hypoplasia associated with an in utero or a neonatal viral infection is most common in cats and cattle and has been reported in pigs goats and chickens 5 11 . However congenital cerebellar disorders such as genetic cerebellar malformations cerebellar malformations of unknown causes and cerebellar abiotrophies also occur in sheep and several breeds of dogs 2 8 13 . Recently in order to determine whether an infective etiology is involved in cerebellar malformations of dogs a polymerase chain reaction PCR to detect the DNA from several infectious agents was performed. Schatzberg et al. 10 described that the cause of the several disorders previously considered idiopathic was a secondary parvoviral infection in dogs using PCR. In this study we describe cerebellar .