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Báo cáo khoa học: "PET-CT staging of the neck in cancers of the oropharynx: patterns of regional and retropharyngeal nodal metastasis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: PET-CT staging of the neck in cancers of the oropharynx: patterns of regional and retropharyngeal nodal metastasis | Tauzin et al. World Journal of Surgical Oncology 2010 8 70 http www.wjso.eom content 8 1 70 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access PET-CT staging of the neck in cancers of the oropharynx patterns of regional and retropharyngeal nodal metastasis 11 2 3 4 1 Marcie Tauzin Amy Rabalais Joseph L Hagan Charles G Wood Robert L Ferris Rohan R Walvekar Abstract Objective To study the retropharyngeal lymph node status RPLN by pretreatment PET-CT imaging in patients with squamous cell carcinomas of the oropharynx OPSCC . Study Design Retrospective. Methods 101 patients with a biopsy proven OPSCC were identified. 53 patients meeting inclusion criteria were further analyzed. Results The frequency of RPLN was 20.8 11 53 . Advanced T stage cancer OR 5.6250 95 CI 1.06 - 29.80 p 0.0410 and advanced clinical N stage cancer i.e. N2 had higher odds OR 3.9773 95 CI 0.9628 -16.4291 of being RPLN positive as compared to N0-1 patients. Conclusions Pre-treatment PET-CT can be used as a staging tool to aid in treatment planning of OPSCC as rates of RPLN and nodal metastasis are consistent with those reported in the literature. Advanced T and N stage are associated with a greater odds ratio of being RPLN positive by PET-CT imaging. Introduction Over the last two decades there has been a gradual shift in the presentation of OPSCC with an increased incidence in a younger patient population 1 2 . Radiotherapy or chemoradiotherapy has been advocated as the treatment of choice for oropharyngeal squamous cell carcinoma OPSCC to avoid morbidity of traditional surgical resection 3 4 . However both radiotherapy and chemoradiotherapy also have known severe local adverse effects and systemic toxicities. Additionally treatment with radiotherapy eliminates its future use for management of second head and neck primary cancers up to 25 2 5 . Traditional surgical options for OPSCC are not considered the treatment of choice for management of these tumors due to equivalent survival outcomes .