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Báo cáo khoa học: "Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia | BioMed Central World Journal of Surgical Oncology Research Epstein-Barr virus latent membrane protein-1 LMP-I 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia Hui Shien See1 Yoke Yeow Yap2 Wai Kien Yip1 and Heng Fong Seow 1 Address Department of Pathology Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Malaysia and 2Department of Surgery Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Malaysia Email Hui Shien See - shuishien@yahoo.com Yoke Yeow Yap - yyyap@medic.upm.edu.my Wai Kien Yip - yipwkien@yahoo.com Heng Fong Seow - shf@medic.upm.edu.my Corresponding author Open Access Published 15 February 2008 Received 17 September 2007 World Journal of Surgical Oncology 2008 6 18 doi l0.ll86 l477-78l 9-6-18 Accepted 15 February 2008 This article is available from http www.wjso.cOm content 6 l l8 2008 See et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Nasopharyngeal carcinoma NPC is a human epithelial tumour with high prevalence amongst Chinese in Southern China and South East Asia and is associated with the Epstein-Barr virus EBV . The viral genome harbours an oncogene namely the latent membrane protein l LMPl gene and known variants such as the 30-bp deletion and loss of XhoI restriction site have been found. Less is known about the relationship between these variants and the population characteristics and histological type. Methods In this study the EBV LMPl gene variants from 42 NPC and 10 non-malignant archived formalin fixed paraffin-embedded tissues as well as plasma from another 35 patients with nasopharyngeal carcinoma were determined by using Polymerase Chain Reaction PCR . Statistical analysis was