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Báo cáo khoa học: " Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence. | Chiou et al. Radiation Oncology 2010 5 79 http www.ro-journal.eom content 5 1 79 RADIATION ONCOLOGY RESEARCH Open Access Buccal mucosa carcinoma surgical margin less than 3 mm not 5 mm predicts locoregional recurrence 1 12 1 12 3 4 Wen-Yen Chiou Hon-Yi Lin Feng-Chun Hsu Moon-Sing Lee Hsu-Chueh Ho Yu-Chieh Su Ching-Chih Lee3 Chen-Hsi Hsieh5 Yao-Ching Wang6 7 Shih-Kai Hung1 2 Abstract Background Most treatment failure of buccal mucosal cancer post surgery is locoregional recurrence. We tried to figure out how close the surgical margin being unsafe and needed further adjuvant treatment. Methods Between August 2000 and June 2008 a total of 110 patients with buccal mucosa carcinoma 25 with stage I 31 with stage II 11 with stage III and 43 with Stage IV classified according to the American Joint Committee on Cancer 6th edition were treated with surgery alone n 32 surgery plus postoperative radiotherapy n 38 or surgery plus adjuvant concurrent chemoradiotherapy n 40 . Main outcome measures The primary endpoint was locoregional disease control. Results The median follow-up time at analysis was 25 months range 4-104 months . The 3-year locoregional control rates were significantly different when a 3-mm surgical margin 3 versus 3 mm 71 versus 95 p 0.04 but not a 5-mm margin 75 versus 92 p 0.22 was used as the cut-off level. We also found a quantitative correlation between surgical margin and locoregional failure hazard ratio 2.16 95 confidence interval 1.14 - 4.11 p 0.019 . Multivariate analysis identified pN classification and surgical margin as independent factors affecting disease-free survival and locoregional control. Conclusions Narrow surgical margin 3 mm but not 5 mm is associated with high risk for locoregional recurrence of buccal mucosa carcinoma. More aggressive treatment after surgery is suggested. Background The incidence of buccal mucosa carcinoma has rapidly increased in Taiwan in recent decades major risk factors for this disease are smoking alcohol drinking