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Báo cáo khoa học: " Hypofractionated radiotherapy after conservative surgery for breast cancer: analysis of acute and late toxicity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Hypofractionated radiotherapy after conservative surgery for breast cancer: analysis of acute and late toxicity. | Deantonio et al. Radiation Oncology 2010 5 112 http www.ro-journal.eom content 5 1 112 RADIATION ONCOLOGY RESEARCH Open Access Hypofractionated radiotherapy after conservative surgery for breast cancer analysis of acute and late toxicity 1 f I 1 1 1 r- -I- -2 2 Letizia Deantonio Giuseppina Gambaro Debora Beldi Laura Masini Sara Tunesi Corrado Magnani Marco Krengli1 Abstract Background A variety of hypofractionated radiotherapy schedules has been proposed after breast conserving surgery in the attempt to shorten the overall treatment time. The aim of the present study is to assess acute and late toxicity of using daily fractionation of 2.25 Gy to a total dose of 45 Gy to the whole breast in a mono-institutional series. Methods Eighty-five women with early breast cancer were assigned to receive 45 Gy followed by a boost to the tumour bed. Early and late toxicity were scored according to the Radiation Therapy Oncology Group criteria. For comparison a group of 70 patients with similar characteristics and treated with conventional fractionation of 2 Gy to a total dose of 50 Gy in 25 fractions followed by a boost was retrospectively selected. Results Overall median treatment duration was 29 days for hypofractionated radiotherapy and 37 days for conventional radiotherapy. Early reactions were observed in 72 85 85 patients treated with hypofractionation and in 67 70 96 patients treated with conventional fractionation p 0.01 . Late toxicity was observed in 8 patients 10 in the hypofractionation group and in 10 patients 15 in the conventional fractionation group respectively p 0.4 . Conclusions The hypofractionated schedule delivering 45 Gy in 20 fractions shortened the overall treatment time by 1 week with a reduction of skin acute toxicity and no increase of late effects compared to the conventional fractionation. Our results support the implementation of hypofractionated schedules in clinical practice. Background Radiotherapy RT reduces the risk of local relapse and .