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Báo cáo khoa học: " Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. | Radiation Oncology BioMed Central Research Radiosensitization by 2-benzoyl-3-phenyl-6 7-dichloroquinoxaline 1 4-dioxide under oxia and hypoxia in human colon cancer cells Wafica Itani1 Fady Geara2 Joelle Haykal1 Makhluf Haddadin3 and Hala Gali-Muhtasib 1 Open Access Address Department of Biology American University of Beirut Beirut Lebanon 2Department of Radiation Oncology American University of Beirut Beirut Lebanon and 3Department of Chemistry American University of Beirut Beirut Lebanon Email Wafica Itani - wsi02@aub.edu.lb Fady Geara - fg00@aub.edu.lb Joelle Haykal - jmh05@aub.edu.lb Makhluf Haddadin - haddadin@aub.edu.lb Hala Gali-Muhtasib - amro@aub.edu.lb Corresponding author Published 03 January 2007 Received 15 September 2006 Radiation Oncology 2007 2 1 doi 10.1186 1748-7I7X-2-1 Accepted 03 January 2007 This article is available from http www.ro-journal.cOm content 2 1 1 2007 Itani et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The sensitizing effects of 2-benzoyl-3-phenyl-6 7-dichloroquinoxaline 1 4-dioxide DCQ and ionizing radiation IR were determined in four colon cancer cells and in FHs74Int normal intestinal cells. Methods Cell cycle modulation TUNEL assay clonogenic survival and DNA damage were examined under oxia or hypoxia. Effects on apoptotic molecules and on p-Akt and Cox-2 protein expression were investigated. Results The four cell lines responded differently to DCQ IR HT-29 cells were most resistant. Combination treatment caused significant increases in preG1 apoptosis in HCT-116 while G2 M arrest occurred in DLD-1. DCQ potentiated IR effects more so under hypoxia than oxia. Preexposure of DLD-1 to hypoxia induced 30 apoptosis and G2 M arrest in oxia. The survival rate was 50