Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo khoa học: "Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model"

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú y đề tài: Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model. | Acta Veterinaria Scandinavica BioMed Central Research Few alterations in clinical pathology and histopathology observed in a CYP2C18 19 humanized mice model Susanne Lofgren 1 Stina Ekman2 Ylva Terelius3 and Ronny Fransson-Steen1 Address 1Safety Assessment Sweden AstraZeneca R D Sodertalje S-151 85 Sodertalje Sweden 2Department of Biomedical Sciences and Veterinary Public Health Division of Pathology Pharmacology Toxicology Box 7028 SLU S-750 07 Uppsala Sweden and 3Medivir AB P.O. Box 1086 S-141 22 Huddinge Sweden Email Susanne Lofgren - susanne.lofgren@astrazeneca.com Stina Ekman - stina.ekman@bvf.slu.se YlvaTerelius - Ylva.Terelius@medivir.com Ronny Fransson-Steen - ronny.fransson-steen@astrazeneca.com Corresponding author Open Access Published 27 November 2008 Acta Veterinaria Scandinavica 2008 50 47 doi l0.ll 86 1751-0147-50-47 Received 2 July 2008 Accepted 27 November 2008 This article is available from http www.actavetscand.eom content 50 l 47 2008 Lofgren et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background This study was performed to characterize a gene-addition transgenic mouse containing a BAC bacterial artificial chromosome clone spanning the human CYP2CI8 I9 genes tg-CYP2CI8 I9 . Methods Hemizygous tg-CYP2C 18 19 II week old mice were compared with wild-type littermates to obtain information regarding clinical status clinical pathology and anatomical pathology. After one week of clinical observations blood samples were collected organs weighed and tissues collected for histopathology. Results In males the tissue weights were lower in tg-CYP2CI8 I9 than in wild-type mice for brain p 0.05 adrenal glands p 0.05 and brown