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Báo cáo khoa học: "nti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model"

Vol Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model. | Available online http ccforum.eom content 9 6 R735 Research Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model Heinz R Redl1 Ulrich Martin2 Anna Khadem3 Linda E Pelinka4 and Martijn van Griensven5 Professor Director Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Donaueschingenstrasse 13 A-1200 Vienna Austria 2Managing director La Merie S.L. Passatge Jordi Ferran 20 E-08028 Barcelona Spain 3Senior technical assistant Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Donaueschingenstrasse 13 A-1200 Vienna Austria 4Assistant professor consultant anesthesiologist Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Donaueschingenstrasse 13 A-1200 Vienna Austria 5Professor associate director Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Donaueschingenstrasse 13 A-1200 Vienna Austria Corresponding author Heinz R Redl office@lbitrauma.org Received 14 Apr 2005 Revisions requested 6 Jun 2005 Revisions received 4 Sep 2005 Accepted 13 Sep 2005 Published 8 Nov 2005 Critical Care 2005 9 R735-R744 DOI 10.11 86 cc3825 This article is online at http ccforum.com content 9 6 R735 2005 Redl et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Anti-adhesion molecule therapy prevents leukocytes from extravasating. During exaggerated inflammation this effect is wanted however during infection blocking diapedesis may be detrimental. In this study therefore the potential risks of anti-L-selectin antibody therapy were evaluated in a primate model of sepsis. Methods Sixteen baboons were anesthetized and randomized into two groups. The experimental group received 2 mg kg of the anti-L-selectin .