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Báo cáo khoa học: "Evidence-Based Medicine Journal Club EBM Journal Club Section Editor: Eric B. Milbrandt, MD, MPH"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evidence-Based Medicine Journal Club EBM Journal Club Section Editor: Eric B. Milbrandt, MD, MPH. | Available online at http ccforum content 10 1 304 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Early recombinant activated factor VII for intracerebral hemorrhage reduced hematoma growth and mortality while improving functional outcomes Lillian L. Emlet1 and David Crippen2 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Associate Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 6 January 2006 This article is online at http ccforum content 10 1 304 2006 BioMed Central Ltd Critical Care 2006 10 304 DOI 10.1186 cc3978 Expanded Abstract Citation Mayer SA Brun NC Begtrup K Broderick J Davis S Diringer MN Skolnick BE Steiner T Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 2005 352 777-785 1 . Hypothesis Recombinant activated factor VIIa rFVIIa can effectively reduce hematoma growth and improve outcomes when given within 4 hours of symptom onset in patients with acute intracerebral hemorrhage. Methods Design International multi-center randomized placebo-controlled trial. Setting Emergency departments and intensive care units in 73 hospitals in 20 countries. Subjects 399 adults age 18 years or older with spontaneous intracerebral hemorrhage documented by CT scanning within 3 hours of onset of symptoms. Exclusion criteria included a score of 3 to 5 on the Glasgow Coma Scale indicating deep coma planned surgical evacuation of hematoma within 24 hours after admission secondary intracerebral hemorrhage related to aneurysm arteriovenous malformation trauma or other causes known use of oral anticoagulant agents known thrombocytopenia history of coagulopathy acute sepsis crush injury or disseminated intravascular coagulation pregnancy preexisting .