Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: " Characterization of APOBEC3G binding to 7SL RNA"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Characterization of APOBEC3G binding to 7SL RNA. | Retrovirology BioMed Central Research Characterization of APOBEC3G binding to 7SL RNA Daniel Bach 1 Shyam PeddD1 Bastien Mangeat1 2 Asvin Lakkaraju3 Katharina Strub3 and Didier Trono 1 Open Access Address 1Global Health Institute School of Life Sciences and Frontiers in Genetics National Center for Competence in Research Ecole Polytechnique Fédérale de Lausanne EPFL CH-1015 Lausanne Switzerland - Departments of Dermatology and Venerology University Hospital and of Microbiology and Molecular Medicine Faculty of Medicine University of Geneva Geneva Switzerland and 3Department of Cell Biology University of Geneva CH-1211 Geneva Switzerland Email Daniel Bach - dani.bach@gmail.com Shyam Peddi - shyamsunder.peddi@epfl.ch Bastien Mangeat - bastien.mangeat@medecine.unige.ch Asvin Lakkaraju - asvin.lakkaraju@cellbio.unige.ch Katharina Strub - katarina.strub@cellbio.unige.ch Didier Trono - didier.trono@epfl.ch Corresponding author fEqual contributors Published 2 July 2008 Received 23 October 2007 Retrovirology 2008 5 54 doi 10.1186 1742-4690-5-54 Accepted 2 July 2008 This article is available from http www.retrovirology.cOm content 5 1 54 2008 Bach et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retroviruses such as human immunodeficiency virus HIV hepadnaviruses such as hepatitis B virus HBV and with the retrotransposition of endogenous retroelements such as long-interspersed nuclear elements LINE and Alu. Here we show that APOBEC3G but not other APOBEC3 family members binds 7SL RNA the common ancestor of Alu RNAs that is specifically recruited into HIV virions. Our data further indicate that APOBEC3G recognizes 7SL RNA and