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Báo cáo khoa học: "opeptin, a novel prognostic biomarker in ventilator-associated pneumonia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia. | Available online http ccforum.eom content 1 2 1 R11 Research Copeptin a novel prognostic biomarker in ventilator-associated pneumonia Renato Seligman1 2 Jana Papassotiriou3 Nils G Morgenthaler3 Michael Meisner4 and Paulo JZ Teixeira2 Hospital de Clínicas de Porto Alegre Rua Ramiro Barcelos 2350 90035-003 Porto Alegre Brazil 2Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos 2400 - 4o Andar 90035-003 Porto Alegre Brazil 3Research Department BRAHMS AG Neuendorfstrasse 25 D-16761 Hennigsdorf bei Berlin Germany 4Hospital of Dresden-Neustadt Industriestrasse 40 D-011 29 Dresden Germany Corresponding author Renato Seligman reseligman@hcpa.ufrgs.br Received 15 Oct 2007 Revisions requested 13 Nov 2007 Revisions received 16 Jan 2008 Accepted 5 Feb 2008 Published 5 Feb 2008 Critical Care 2008 12 R11 doi 10.1186 cc6780 This article is online at http ccforum.com content 12 1 R11 2008 Seligman et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background The present study sought to investigate the correlation of copeptin with the severity of septic status in patients with ventilator-associated pneumonia VAP and to analyze the usefulness of copeptin as a predictor of mortality in VAP. Methods The prospective observational cohort study was conducted in a teaching hospital. The subjects were 71 patients consecutively admitted to the intensive care unit from October 2003 to August 2005 who developed VAP. Copeptin levels were determined on day 0 and day 4 of VAP. Patients were followed for 28 days after the diagnosis when they were considered survivors. Patients who died before day 28 were classified as nonsurvivors. There were no interventions. Results Copeptin levels increased from sepsis to severe .