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Báo cáo y học: "Bench to bedside: A role for erythropoietin in sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Bench to bedside: A role for erythropoietin in sepsis. | Walden et al. Critical Care 2010 14 227 http ccforum.eom content 14 4 227 CRITICAL CARE REVIEW L_ Bench to bedside A role for erythropoietin in sepsis Andrew P Walden 1 J Duncan Young1 and Edward Sharpies2 Abstract Sepsis is the systemic inflammatory response to infection and can result in multiple organ dysfunction syndrome with associated high mortality morbidity and health costs. Erythropoietin is a well-established treatment for the anaemia of renal failure due to its anti-apoptotic effects on red blood cells and their precursors. The extra-haemopoietic actions of erythropoietin include vasopressor anti-apoptotic cytoprotective and immunomodulating actions all of which could prove beneficial in sepsis. Attenuation of organ dysfunction has been shown in several animal models and its vasopressor effects have been well characterised in laboratory and clinical settings. Clinical trials of erythropoietin in single organ disorders have suggested promising cytoprotective effects and while no randomised trials have been performed in patients with sepsis good quality data exist from studies on anaemia in critically ill patients giving useful information of its pharmacokinetics and potential for harm. An observational cohort study examining the microvascular effects of erythropoietin is underway and the evidence would support further phase II and III clinical trials examining this molecule as an adjunctive treatment in sepsis. Introduction Sepsis is the systemic inflammatory response to infection. The clinical syndrome can range from mild constitutional upset to overt septic shock with the failure of multiple organ systems reflecting the complex pathogenesis of sepsis involving immunological and coagulation pathways 1 2 . The burden from sepsis remains high with worldwide incidence ranging from 0.5 to 1.5 per Correspondence apwalden@hotmail.com 1Adult Intensive Care Unit John Radcliffe Hospital Headley Way Headington Oxford OX3 9DU UK Full list of author .