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Báo cáo y học: "Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm. | Research Open Access Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm Aminata TouréH Emily J ClementeH Peter JI Ellis Shantha K Mahadevaiah Obah A Ojarikre Penny AF Ball Louise Reynard Kate L Loveland Paul S Burgoyne and Nabeel A Affara Addresses Division of Developmental Genetics MRC National Institute for Medical Research Mill Hill London NW7 1AA UK. University of Cambridge Department of Pathology Tennis Court Road Cambridge CB2 1QP UK. Monash Institute of Medical Research Monash University and The Australian Research Council Centre of Excellence in Biotechnology and Development Melbourne Victoria 3168 Australia. H These authors contributed equally to this work. Correspondence Paul S Burgoyne. E-mail pburgoy@nimr.mrc.ac.uk Published 2 December 2005 Genome Biology 2005 6 R102 doi l0.ll86 gb-2005-6-l2-rl02 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 l2 Rl02 Received 17 June 2005 Revised 19 September 2005 Accepted 27 October 2005 2005 Touré et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The male-specific region of the mouse Y chromosome long arm MSYq is comprised largely of repeated DNA including multiple copies of the spermatid-expressed Ssty gene family. Large deletions of MSYq are associated with sperm head defects for which Ssty deficiency has been presumed to be responsible. Results In a search for further candidate genes associated with these defects we analyzed changes in the testis transcriptome resulting from MSYq deletions using testis cDNA microarrays. This approach aided by accumulating mouse MSYq sequence information .