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báo cáo khoa học: " MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma | Journal of Experimental Clinical Cancer Research Cai et al. Journal of Experimental Clinical Cancer Research 2011 30 73 http www.jeccr.eom content 30 1 73 RESEARCH Open Access MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma Kemin Cai Yu Wangt and Xueli Bao Abstract MiR-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. However the underlying mechanism of miR-106b involved in laryngeal carcinoma remains elusive. Here we showed that reduction of miR-106b induced cell cycle G0 G1 arrest by targeting tumor suppressor RB in human laryngeal carcinoma cells. Further Introducing RB cDNA without 3 UTR abrogated miR-106b-induced cell proliferation. Finally there was an inverse relationship between RB and miR-106b expression in laryngeal carcinoma tissues. To our knowledge these data indicate for the first time that miR-106b directly regulate cell cycle by targeting RB in laryngeal carcinoma and that miR-106b could be potential therapeutic approaches for laryngeal carcinoma. Keywords laryngeal carcinoma miR-106b RB cell proliferation Background Laryngeal carcinoma is a common head and neck malignancy with high incidence as it accounts for approximately 2.4 of new malignancies worldwide every year 1 2 . Despite recent advances in cancer treatment the prognosis for patients with laryngeal carcinoma especially at advanced stage remains poor. Therefore it is essential to investigate the mechanism involved in the development and progression of laryngeal carcinoma. MicroRNAs miRNAs are a new class of small noncoding RNAs and regulate gene expression by binding to the 3 -untranslated regions 3 UTRs of specific mRNAs. miRNAs could function as oncogenic miRNAs or tumor suppressor miRNAs playing crucial roles in the development and progression of carcer 3 4 . Recent studies have indicated that frequent deregulation of miRNA in laryngeal carcinoma 5 6 . Let-7a was significantly downregulated both in human .