A second paragraph will address Diffuse Reflectance Spectroscopy (DRS) that has been tested on phantoms mimicking melanoma. A third paragraph will talk about two techniques that have given preliminary results on potential Breslow index determination: the first one, infrared microimaging, performed on fixed and paraffin-embedded tissues (. after excision of the tumour) and the second one, photoacoustic microscopy, performed in vivo on mice on which melanoma human cells were xenografted. Finally a fourth paragraph will address the topic of two techniques that have already shown excellent results in the area of skin thickness determination but for which no studied has yet been carried out to determine Breslow thickness although.